Anti tubercular drugs mechanism of action and adverse effects thomas kurian 2. This infection mainly affects the lungs but can also affect many other organ systems. Antituberculosis agents are drugs used to treat tuberculosis, an infectious disease caused by mycobacterium tuberculosis. The antitubercular drugs are listed in table 411 by their mechanism of action. This video is about classification of antitubercular drugs. Molecular studies of the mechanism of action of antitubercular drugs have elucidated the genetic basis of drug resistance i. It is tuberculocidal but less effective than isoniazid or rifampin.
Adverse effects of antituberculosis drugs or drug interactions among. Rifampin binds to the betasubunit of the holoenzyme. The mechanism of action for pyrazinamide is not clearly. These drugs act on mtb by inhibiting protein synthesis, inhibiting cell wall synthesis, or various other mechanisms.
Mechanism of action is via inhibition of dnadependent rna polymerase at the initiation step. Despite the favorable toxicity profile of thioridazine relative to. Pdf on sep 1, 2010, marcos arbex and others published antituberculosis drugs. Many classes of drugs, with different mechanism of action have activity against mycobacterium tuberculosis. Introduction historically, tuberculosis tb has been associated with significant morbidity and mortality, and still remains a major global health problem. Rare side effects have been reported in all other organ systems. Ocular side effects of antitubercular drugs a focus on prevention, early detection and management. Antitubercular drugs classificationfirst line and second. Because inh is the most commonly used antituberculosis drug, resistance.
The information compiled by the global alliance for tb drug development. Mechanisms of action of tb drugs under development nitroimidazoles, sq109, meropenem, and benzothiazinones act on cell wall synthesis. Although the mode of action is not known with certainty, ethambutol. Request pdf action mechanism of antitubercular isoniazid activation of the antitubercular isoniazid inh by the mycobacterium tuberculosis katg produces an inhibitor for enoyl reductase inha. Tuberculosis drug information guide curry international. The major effects of drug therapy include reduction of cough and, therefore, reduction of the infectiousness of the patient. Here we provide free mcqs, flashcard, theory lecture of pci syllabus a. The solutionpharmacy is the completely dedicated channel for the pharmacy profession. The mechanisms of action of the various antitubercular drugs vary depending on the drug.
The current antitb drug research and development pipeline. Theoretical basis of chemotherapy of tuberculosis population a live extracellularly in pulmonary cavities metabolically very active and rapidly growing in a hyperoxic and alkaline ph environment. Drug interactions, adverse effects, and use in special situations. Anti tubercular drugs mechanism of action and adverse. Tuberculosis drug information guide, 2nd edition was created through a collaboration of the curry. Action mechanism of antitubercular isoniazid request pdf. For some drugs, the mechanisms of action have not been fully identified. Clinical pharmacology and therapeutic drug monitoring of first. It was the first clinically useful anti tubercular drug. Pdf file of the complete article 283k, or click on a page image below to browse page by.